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 | Morriss R et al. Clinical effectiveness of active Alpha-Stim AID versus sham Alpha-Stim AID in major depression in primary care in England (Alpha-Stim-D): a multicentre, parallel group, double-blind, randomised controlled trial. www.thelancet.com/psychiatry Published online January 29, 2023 https://doi.org/10.1016/S2215-0366(23)00007-X | Major Depression | RCT |
 | Patel s et al. A randomised controlled trial investigating the clinical and cost-effectiveness of Alpha- Stim AID cranial electrotherapy stimulation (CES) in patients seeking treatment for moderate severity depression in primary care (Alpha-Stim-D Trial). Trials (2022) 23:250. | Depression, Cost effectiveness | RCT |
 | Park BS et al. Comparison of the effects of cranial electrotherapy stimulation and midazolam as preoperative treatment in geriatric patients: A CONSORT-compliant randomized controlled trial. Medicine (Baltimore). 2022 Sep 2; 101(35). | Geriatric patients, Anxiety | RCT |
 | Royal, S., Keeling, S., Kelsall, N., Price, L., Fordham, R., Xydopoulos, G., et al. Feasibility, acceptability and costs of nurse-led Alpha-Stim cranial electrostimulation to treat anxiety and depression in university students. BMC Primary Care. 2022; 23:97. | Anxiety, Depression, Students | open |
 | Griffiths, C., Leathlean, C., Smart, D., Zafar, A., Hall, C-L., & Deeks, S. Alpha-Stim Cranial Electrotherapy Stimulation (CES) for Anxiety Treatment: Outcomes in a United Kingdom (UK) Primary Care Practice. Open Journal of Psychiatry. 2021, 11: 186-201. | Anxiety | open |
 Link Alpha-Stim USA | Kong, S., Gao, C., & Yang, Z. Effects of Cranial Electrotherapy Stimulation on the Levels of HPA, BDNF and Clinical Symptoms in Patients with Mild Depression. Journal of International Psychiatry. 2021; 48(1). | Mild Depression | RCT |
 Link Alpha-Stim USA | Gao, C., Kong, S., Duan, H., Yang, Z., Li, D. Effects of cranial electrotherapy stimulation on suicidal ideation and event-related potentials in patients with treatment-resistant depression. China Journal of Health Psychology. 2021; 29(2):183-188. | Treatment Resistant Depression, Suicidal Ideation | RCT |
 Link Alpha-Stim USA | Liu, Y., Xie, L., Wang, L., Zhao, R-J., Xu F., & Wang, W-S. Effect of CES combined with flupentixol-melitracen for depression after stroke. Chinese Journal of Misdiagnosis. 2021; 16(2):106-109. | Depression, Stroke | RCT |
 Link Alpha-Stim USA | Liu, E., Zhang, W., Wang, J., Zhao, F., & Bai, Y. Acupuncture combined with cranial electrotherapy stimulation on generalized anxiety disorder: A randomized controlled trial. Chinese Acupuncture & Moxibustion. 2020; 40(11). | Anxiety | RCT |
 | Platoni K, Oakley R, Haltiwanger SG, Kirsch TB, Marksberry J and Price LR. First responder research shows that electrical brain stimulation helps control anxiety, insomnia, and depression. JJ Psych Behav Sci. 2019; 6(1): 25-31. | Anxiety, Depression, Insomnia, First responder | open |
 | Morriss R, Xydopoulos G, Craven M, Price L, Fordham R. Clinical effectiveness and cost minimisation model of Alpha-Stim cranial electrotherapy stimulation in treatment seeking patients with moderate to severe generalised anxiety disorder. Journal of Affective Disorders. 2019, June; 253:426-437. | Anxiety, Cost minimisation | open |
 | Kirsch TB, Kuhn J, Price LR, Marksberry J, Haltiwanger SG. A novel medical device that relieves anxiety, depression and pain while improving sleep in a population of teachers. Journal of Depression and Anxiety. 2019; 8:334. | Pain, Anxiety, Depression | open |
 Link Alpha-Stim USA | Ren, Y., Zhu, Y., Yang, J., & Ding, F. Efficacy of Cranial Electrotherapy Stimulation on Anxiety and Sleep Qualities Among Elderly Patients with Chronic Sleep Disorders. Chinese Journal Modern Nursing. 2019; 25(24). | Chronic sleep disorder | RCT |
 | Yennurajalingam S, Kang D-H, Hwu W-J, Padhye NS, Masino C, Dibaj SS, Liu DD, Williams JL, Lu Z, Bruera E. Cranial electrotherapy stimulation for the management of depression, anxiety, sleep disturbance, and pain in patients with advanced cancer: a preliminary study. Journal of Pain and Symptom Management. 2018, 55(2): 198–206. | Cancer, Pain, Anxiety, Insomnia, Depression, CES | open (abstract) |
 Link Alpha-Stim USA | Lyu, X. Effect of CES combined with escitalopram on quality of life and activities of daily living of patients with depression after cerebral infarction. Chinese Journal of Practical Nervous Diseases, 21(22), 2018. | Depression, Stroke | RCT |
 Link Alpha-Stim USA | Roh, HT. & So, W-Y. Cranial electrotherapy stimulation affects mood state but not levels of peripheral neurotrophic factors or hypothalamic-pituitary-adrenal axis regulation. Technology and health care: Official Journal of the European Society for Engineering and Medicine. 2017; 25(3):403–412. | Mood, Neurotrophic factors | RCT |
 | Hare JP, Misialek LH, Palis K and Wong C. Using cranial electrotherapy stimulation therapy to treat behavioral health symptoms in a combat operational setting. Military Medicine. 2016; 181(11):1410-1412. | CES, Military | Report |
 | Mellen RR, Case J and Ruiz DJ. Cranial electrotherapy stimulation (CES) As a treatment for reducing stress and improving prefrontal cortex functioning in victims of domestic violence. International Association for Correctional and Forensic Psychology Newsletter. 48(3):12-15, 2016. | CES, Violence, Victim, Anxiety | Report |
 | Rickabaugh K et al. A retrospective review of patient perception of Alpha-Stimulation treatment. Poster presented at The Military Health System Symposium in Kissimmee, Florida. 2016; August 15-18. | CES, Military | Poster |
 | Hill N. The Effects of Alpha Stimulation on Induced Anxiety. Electronic Theses and Dissertations 2015 | CES, induced anxiety | RCT |
 Link Alpha-Stim USA | Ou, Y, Li, C. Sertraline combined Alpha-Stim clinical observations on the treatment of 30 cases of generalized anxiety disorder. Chinese Journal of Ethnomedicine and Ethnopharmacy. 2015; 24(17):73-75. | Anxiety disorder, Sertraline | open |
 Link Alpha-Stim USA | Luo, H-D, Luo, H-L., Hong, L-F Comparative Observation between Single Use of Fluoxetine and Its Combination with CES. Chin J Mod Drug Appl. 2015; 9(7). | Fluoxetine, Depression | RCT |
 Link Alpha-Stim USA | Wang, X., Xia, P., Lin, Q., Cheng, K., Chen, A., Yang, T., & Xueping, L. I. The effects of cranial electrotherapy stimulation therapy combined with psychological intervention in treating post-stroke depression. Chinese Journal of Physical Medicine and Rehabilitation.2015; 37(9):680-682. | Depression, Stroke | RCT |
 Link Alpha-Stim USA | Wei Y., Yang Z., Pan H., Zhao S-J., Fang J-Z. Clinical Efficacy of Assisted Cranial Electrotherapy Stimulation Treatment on Depression. Neural Injury and Functional Reconstruction. July 2014, 9(4):317. | Depression, Anxiety | RCT |
 Link Alpha-Stim USA | Kong, J., Wu, J., Jiang, X., et al. Treatment of Sleep Disorder with Cranial Electrotherapy Stimulation Combined with Psychological Counseling in Postmenopausal Women: A Randomized Study. Chinese Journal of Medicinal Guide. 2014; 921, 16(6):(Serial No.128). | Postmenopausal, Women | RCT |
 | LU Ling, HU Jun. A comparative study of anxiety disorders treatment with Paroxetine in combination with cranial electrotherapy stimulation therapy. Medical Innovation of China, 11(08):080-082, 2014. | CES, Paroxetine, Anxiety | RCT |
 | Barclay TH, Barclay RD. A clinical trial of cranial electrotherapy stimulation for anxiety and comorbid depression. Journal of Affective Disorders, 164:171-177, 2014. | CES, Cranial Electrotherapy Stimulation, Anxiety, Depression | RCT |
 | Kirsch DL, Price LR, Nichols F, Marksberry JA and Platoni KT. Efficacy of Cranial Electrotherapy Stimulation for Anxiety, PTSD, Insomnia, and Depression: US Military Service Members and Veterans Self Reports. The United States Army Medical Department Journal. October-December 2014:46-54. | CES, Cranial Electrotherapy Stimulation, Anxiety, Depression, PTSD, Insomnia | Report |
 | Amr, Mostafa, El-Wasify, Mahmoud, Elmaadawi, Ahmed, Roberts, Jeannie, and El-Mallakn, Rif. Cranial Electrotherapy Stimulation for the Treatment of Chronically Symptomatic Bipolar Patients. Journal of ECT, 29(2): 31-32, 2013. | CES, Cranial Electrotherapy Stimulation, bipolar | RCT |
 | Lee, S-H, Kim, W-Y, Lee C-H, Min, T-J, Lee Y-S, Kim J-H. Effects of cranial electrotherapy stimulation on preoperative anxiety, pain and endocrine response. Journal of International Medical Research, 41(6) 1788–1795, 2013. | CES, Cranial Electrotherapy Stimulation, Preoperative Anxiety, Endocrine | RCT |
 | Koleoso ON, Osionwo HO, Akkhigbe. The role of relaxation therapy and cranial electrotherapy stimulation in the management of dental anxiety in Nigeria. ISOR Journal of Dental and Medical Sciences, 2013, 10(4): 51-57. | CES, Cranial Electrotherapy Stimulation, Dental, Anxiety | RCT |
 | Mellen, Ronald R. and Mackey,Wade. Reducing Sheriff’s Officers’ Symptoms of Depression Using Cranial Electrotherapy Stimulation (CES): A Control Experimental Study. The Correctional Psychologist, 41(1):9-15, 2009. | CES, Cranial Electrotherapy Stimulation, Depression | RCT |
 | Mellen, Ronald R. and Mackey, Wade. Cranial Electrotherapy Stimulation (CES) and the Reduction of Stress Symptoms in a Sheriff’s Jail Security and Patrol Offficer Population: A Pilot Study. AmericanJail’s, 11/12 2008: 32-38. | CES, Cranial Electrotherapy Stimulation, Stress | RCT |
 | Strentzsch, Julie A. An examination of cranial electrotherapy stimulation (CES) on alpha-amylase levels, cortisol levels and state-trait anxiety scores in the chronically mentally ill. Doctoral Dissertation, Saint Mary’s University, San Antonio, Texas, 2008. | CES, Cranial Electrotherapy Stimulation, Cortisol, Alpha-Amylase, Anxiety, Mentally Ill | RCT |
 | Bystritsky, A., Kerwin, L., Feusner, J. A pilot study of cranial electrotherapy stimulation for generalized anxiety disorder. Journal of Clinical Psychiatry, 69:412-417, 2008. | CES, Cranial Electrotherapy Stimulation, Anxiety | open |
 | Chen Yixin, Yu Lin, Zhang Jiuping, Li Lejia, Chen Tunong, Chen Yi. Results of cranial electrotherapy stimulation to children with mixed anxiety and depressive disorder. Shanghai Archives of Psychiatry, 19(4):203-205, 2007. | CES, Cranial Electrotherapy Stimulation, Children, CCMD-3, Anxiety, Depression | RCT |
 | Lu XY, Wang AH, Li Y, Zhang JS, Liu BX. Safety and effectiveness of cranial electrotherapy stimulation in treating children with emotional disorders. Chinese Journal of Clinical Rehabilitation, 9(8):96-7, 2005. | CES, Cranial Electrotherapy Stimulation, Children, CCMD-3, Anxiety, Depression | open |
 | Gilula, Marshall F. and Barach, Paul R. Cranial Electrotherapy Stimulation: a Safe Neuromedical Treatment for Anxiety, Depression or Insomnia. Southern Medical Journal. 2004; 97(12):1269-1270. | CES, Cranial Electrotherapy Stimulation, Anxiety, Depression, Insomnia, safe, Side Effects | Meta Analyses |
 | Winick, Reid L. Cranial Electrotherapy Stimulation (CES): A Safe and Effective Low Cost Means of Anxiety Control in a Dental Practice. General Dentistry, 47(1):50-55, 1999. | CES, Cranial Electrotherapy Stimulation, Dental, Anxiety | RCT |
 | Voris, Marshall D. An Investigation of the Effectiveness of Cranial Electrotherapy Stimulation in the Treatment of Anxiety Disorders Among Outpatient Psychiatric Patients, Impulse Control Parolees and Pedophiles. Delos Mind/Body Institute Newsletter, Dallas and Corpus Cristi, Texas, 1995. | CES, Cranial Electrotherapy Stimulation, Anxiety, Impulse Control | RCT |
 | Gibson, Thomas H. and O’Hair, Donald E. Cranial Application of Low Level Transcranial Electrotherapy vs. Relaxation Instruction in Anxious Patients. American Journal of Electromedicine, 4(1):18-21, 1987. Doctoral dissertation (TG), California School of Professional Psychology, 152 pages, 1983. | CES, Cranial Electrotherapy Stimulation, Anxiety, Relaxation | RCT |
 | Overcash, Stephen J. Cranial Electrotherapy Stimulation in Patients Suffering from Acute Anxiety Disorders. American Journal of Electromedicine, 16(1):49-51, 1999. | CES, Cranial Electrotherapy Stimulation, Anxiety | open |